Assay Detail
Binding
CHEMBL874560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human androgen receptor expressed in Escherichia coli
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
11beta-alkyl-Delta9-19-nortestosterone derivatives: high-affinity ligands and potent partial agonists of the androgen receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.90 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184313 | — | — | 1 | 10.00 |
| CHEMBL2311179 | — | — | 1 | 9.70 |
| CHEMBL189306 | — | — | 1 | 9.70 |
| CHEMBL186254 | — | — | 1 | 9.10 |
| CHEMBL184228 | — | — | 1 | 8.70 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 8.66 |
| CHEMBL386630 | TESTOSTERONE | 4.0 | 1 | 8.41 |
| CHEMBL186467 | — | — | 1 | 8.18 |
| CHEMBL361245 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184313 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2311179 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL189306 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL186254 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL184228 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL386630 | TESTOSTERONE | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL186467 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL361245 | — | IC50 | = | 22.0 | nM | 7.66 |