Assay Detail
Functional
CHEMBL874634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human peripheral blood mononuclear cell (PBMC)donor C proliferation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.42 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8785 | — | — | 1 | 4.60 |
| CHEMBL8463 | — | — | 1 | 4.52 |
| CHEMBL8483 | — | — | 1 | 4.46 |
| CHEMBL267527 | — | — | 1 | 4.35 |
| CHEMBL8450 | — | — | 1 | 4.19 |
| CHEMBL463321 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8785 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL8463 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL8483 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL267527 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL8450 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL463321 | — | IC50 | = | 230000.0 | nM | - |