Assay Detail
Functional
CHEMBL874829
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Concentration required for growth inhibition of vinblastine resistant human lymphoblastic leukemic cell line (CCRF-CEM/VBL) was determined
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.64 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182739 | — | — | 1 | 8.12 |
| CHEMBL185119 | — | — | 1 | 7.22 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.27 |
| CHEMBL321473 | — | — | 1 | 5.80 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182739 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL185119 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL321473 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1620.0 | nM | 5.79 |