Assay Detail
Functional
CHEMBL874927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of U-46,619-induced inositol phosphate accumulation at human Thromboxane A2 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.38 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361812 | RAMATROBAN | 4.0 | 1 | 8.02 |
| CHEMBL194085 | — | — | 1 | 5.77 |
| CHEMBL373118 | — | — | 1 | 5.34 |
| CHEMBL179036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361812 | RAMATROBAN | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL194085 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL373118 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL179036 | — | IC50 | > | 10000.0 | nM | - |