Assay Detail
Functional
CHEMBL874944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells)
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 60 | 4.66 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298852 | — | — | 1 | 6.55 |
| CHEMBL54004 | — | — | 1 | 6.26 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 6.10 |
| CHEMBL319144 | MINODRONIC ACID | 4.0 | 1 | 5.73 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 5.62 |
| CHEMBL110971 | — | — | 1 | 5.62 |
| CHEMBL55886 | — | — | 1 | 5.46 |
| CHEMBL199858 | — | — | 1 | 5.35 |
| CHEMBL1161778 | — | — | 1 | 5.17 |
| CHEMBL434024 | — | — | 1 | 5.09 |
| CHEMBL417549 | (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 5.05 |
| CHEMBL298547 | — | — | 1 | 4.86 |
| CHEMBL1161777 | — | — | 1 | 4.76 |
| CHEMBL291727 | — | — | 1 | 4.68 |
| CHEMBL292224 | (CYCLOPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.64 |
| CHEMBL55264 | — | — | 1 | 4.60 |
| CHEMBL293116 | — | — | 1 | 4.51 |
| CHEMBL127588 | — | — | 1 | 4.44 |
| CHEMBL56011 | — | — | 1 | 4.44 |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | 4.42 |
| CHEMBL53950 | INCADRONIC ACID | 2.0 | 1 | 4.40 |
| CHEMBL301065 | — | — | 1 | 4.38 |
| CHEMBL55779 | (DICYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.38 |
| CHEMBL412889 | (CYCLOOCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.36 |
| CHEMBL55140 | — | — | 1 | 4.35 |
| CHEMBL291736 | — | — | 1 | 4.35 |
| CHEMBL125188 | — | — | 1 | 4.32 |
| CHEMBL124796 | — | — | 1 | 4.29 |
| CHEMBL52137 | — | — | 1 | 4.29 |
| CHEMBL997 | IBANDRONIC ACID | 4.0 | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298852 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL54004 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL319144 | MINODRONIC ACID | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL110971 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL55886 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL199858 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1161778 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL434024 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL417549 | (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 8890.0 | nM | 5.05 |
| CHEMBL298547 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL1161777 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL291727 | — | IC50 | = | 20890.0 | nM | 4.68 |
| CHEMBL292224 | (CYCLOPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 23080.0 | nM | 4.64 |
| CHEMBL55264 | — | IC50 | = | 25310.0 | nM | 4.60 |
| CHEMBL293116 | — | IC50 | = | 30920.0 | nM | 4.51 |
| CHEMBL127588 | — | IC50 | = | 36420.0 | nM | 4.44 |
| CHEMBL56011 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL53950 | INCADRONIC ACID | IC50 | = | 39650.0 | nM | 4.40 |
| CHEMBL301065 | — | IC50 | = | 41950.0 | nM | 4.38 |
| CHEMBL55779 | (DICYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 42050.0 | nM | 4.38 |
| CHEMBL412889 | (CYCLOOCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 43220.0 | nM | 4.36 |
| CHEMBL291736 | — | IC50 | = | 44630.0 | nM | 4.35 |
| CHEMBL55140 | — | IC50 | = | 44480.0 | nM | 4.35 |
| CHEMBL125188 | — | IC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL124796 | — | IC50 | = | 51190.0 | nM | 4.29 |
| CHEMBL52137 | — | IC50 | = | 51220.0 | nM | 4.29 |
| CHEMBL997 | IBANDRONIC ACID | IC50 | = | 54920.0 | nM | 4.26 |
| CHEMBL197935 | — | IC50 | = | 55060.0 | nM | 4.26 |
| CHEMBL192793 | — | IC50 | = | 56160.0 | nM | 4.25 |
| CHEMBL55557 | — | IC50 | = | 59040.0 | nM | 4.23 |
| CHEMBL55214 | NERIDRONIC ACID | IC50 | = | 59700.0 | nM | 4.22 |
| CHEMBL382754 | — | IC50 | = | 63230.0 | nM | 4.20 |
| CHEMBL58830 | (CYCLOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 68430.0 | nM | 4.17 |
| CHEMBL299717 | (PROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 69250.0 | nM | 4.16 |
| CHEMBL192881 | — | IC50 | = | 68750.0 | nM | 4.16 |
| CHEMBL55359 | — | IC50 | = | 72520.0 | nM | 4.14 |
| CHEMBL374042 | — | IC50 | = | 76700.0 | nM | 4.12 |
| CHEMBL55608 | (BUTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 76140.0 | nM | 4.12 |
| CHEMBL417932 | — | IC50 | = | 80340.0 | nM | 4.09 |
| CHEMBL54472 | N-(HEXAMETHYLENEIMINO)METHYLENEBISPHOSPHONIC ACID | IC50 | = | 89770.0 | nM | 4.05 |
| CHEMBL56556 | — | IC50 | = | 90230.0 | nM | 4.04 |
| CHEMBL218745 | — | IC50 | = | 164300.0 | nM | - |
| CHEMBL870 | ALENDRONIC ACID | IC50 | = | 108800.0 | nM | - |
| CHEMBL54926 | (CYCLOBUTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 120900.0 | nM | - |
| CHEMBL298771 | — | IC50 | = | 126400.0 | nM | - |
| CHEMBL52620 | — | IC50 | = | 234700.0 | nM | - |
| CHEMBL375226 | — | IC50 | = | 226400.0 | nM | - |