Assay Detail
Binding
CHEMBL875016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]rauwolscine from Alpha-2 adrenergic receptor in rat cortical membranes
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT uptake inhibiting and alpha2-antagonistic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 61 | 8.02 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10425 | — | — | 1 | 8.91 |
| CHEMBL9783 | — | — | 1 | 8.77 |
| CHEMBL9925 | — | — | 1 | 8.75 |
| CHEMBL9912 | — | — | 1 | 8.75 |
| CHEMBL9970 | — | — | 1 | 8.75 |
| CHEMBL9924 | — | — | 1 | 8.74 |
| CHEMBL274391 | — | — | 1 | 8.73 |
| CHEMBL9894 | — | — | 1 | 8.73 |
| CHEMBL268258 | — | — | 1 | 8.70 |
| CHEMBL10304 | — | — | 1 | 8.67 |
| CHEMBL10369 | — | — | 1 | 8.58 |
| CHEMBL269171 | — | — | 1 | 8.58 |
| CHEMBL10102 | — | — | 1 | 8.56 |
| CHEMBL274867 | — | — | 1 | 8.56 |
| CHEMBL10347 | RAUWOLSCINE | — | 1 | 8.54 |
| CHEMBL10067 | — | — | 1 | 8.54 |
| CHEMBL276236 | — | — | 1 | 8.47 |
| CHEMBL10411 | — | — | 1 | 8.41 |
| CHEMBL167493 | NAPAMEZOLE | 2.0 | 1 | 8.38 |
| CHEMBL10115 | — | — | 1 | 8.35 |
| CHEMBL10170 | — | — | 1 | 8.34 |
| CHEMBL10066 | — | — | 1 | 8.33 |
| CHEMBL10152 | — | — | 1 | 8.32 |
| CHEMBL9869 | — | — | 1 | 8.31 |
| CHEMBL10068 | — | — | 1 | 8.31 |
| CHEMBL9896 | — | — | 1 | 8.28 |
| CHEMBL10410 | — | — | 1 | 8.27 |
| CHEMBL269402 | — | — | 1 | 8.27 |
| CHEMBL418337 | — | — | 1 | 8.26 |
| CHEMBL10052 | — | — | 1 | 8.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10425 | — | Ki | = | 1.22 | nM | 8.91 |
| CHEMBL9783 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL9912 | — | Ki | = | 1.76 | nM | 8.75 |
| CHEMBL9970 | — | Ki | = | 1.78 | nM | 8.75 |
| CHEMBL9925 | — | Ki | = | 1.77 | nM | 8.75 |
| CHEMBL9924 | — | Ki | = | 1.81 | nM | 8.74 |
| CHEMBL274391 | — | Ki | = | 1.88 | nM | 8.73 |
| CHEMBL9894 | — | Ki | = | 1.86 | nM | 8.73 |
| CHEMBL268258 | — | Ki | = | 2.01 | nM | 8.70 |
| CHEMBL10304 | — | Ki | = | 2.12 | nM | 8.67 |
| CHEMBL10369 | — | Ki | = | 2.65 | nM | 8.58 |
| CHEMBL269171 | — | Ki | = | 2.64 | nM | 8.58 |
| CHEMBL10102 | — | Ki | = | 2.78 | nM | 8.56 |
| CHEMBL274867 | — | Ki | = | 2.73 | nM | 8.56 |
| CHEMBL10067 | — | Ki | = | 2.88 | nM | 8.54 |
| CHEMBL10347 | RAUWOLSCINE | Ki | = | 2.89 | nM | 8.54 |
| CHEMBL276236 | — | Ki | = | 3.42 | nM | 8.47 |
| CHEMBL10411 | — | Ki | = | 3.91 | nM | 8.41 |
| CHEMBL167493 | NAPAMEZOLE | Ki | = | 4.17 | nM | 8.38 |
| CHEMBL10115 | — | Ki | = | 4.51 | nM | 8.35 |
| CHEMBL10170 | — | Ki | = | 4.62 | nM | 8.34 |
| CHEMBL10066 | — | Ki | = | 4.67 | nM | 8.33 |
| CHEMBL10152 | — | Ki | = | 4.82 | nM | 8.32 |
| CHEMBL9869 | — | Ki | = | 4.91 | nM | 8.31 |
| CHEMBL10068 | — | Ki | = | 4.88 | nM | 8.31 |
| CHEMBL9896 | — | Ki | = | 5.21 | nM | 8.28 |
| CHEMBL269402 | — | Ki | = | 5.35 | nM | 8.27 |
| CHEMBL10410 | — | Ki | = | 5.33 | nM | 8.27 |
| CHEMBL418337 | — | Ki | = | 5.45 | nM | 8.26 |
| CHEMBL10052 | — | Ki | = | 5.57 | nM | 8.25 |
| CHEMBL273874 | — | Ki | = | 5.67 | nM | 8.25 |
| CHEMBL10187 | — | Ki | = | 5.73 | nM | 8.24 |
| CHEMBL268463 | — | Ki | = | 6.07 | nM | 8.22 |
| CHEMBL430314 | — | Ki | = | 5.99 | nM | 8.22 |
| CHEMBL9831 | — | Ki | = | 6.71 | nM | 8.17 |
| CHEMBL9938 | — | Ki | = | 6.79 | nM | 8.17 |
| CHEMBL9844 | — | Ki | = | 7.54 | nM | 8.12 |
| CHEMBL269452 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL10451 | — | Ki | = | 8.19 | nM | 8.09 |
| CHEMBL10409 | — | Ki | = | 8.99 | nM | 8.05 |
| CHEMBL10385 | — | Ki | = | 9.27 | nM | 8.03 |
| CHEMBL9886 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL276667 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL274055 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL276826 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL400421 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL10216 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL9860 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL268749 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL269208 | — | Ki | = | 54.3 | nM | 7.26 |