Assay Detail
Binding
CHEMBL875080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for its binding affinity by measuring its ability to displace [3H]granisetron from 5-hydroxytryptamine 3 receptor in rat cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Quaternised renzapride as a potent and selective 5-HT4 receptor agonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.67 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59834 | — | — | 1 | 8.80 |
| CHEMBL62023 | — | — | 1 | 8.40 |
| CHEMBL296522 | RENZAPRIDE | 3.0 | 1 | 8.30 |
| CHEMBL156977 | — | — | 1 | 6.90 |
| CHEMBL350221 | OXITRIPTAN | 3.0 | 1 | 6.80 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59834 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL62023 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL296522 | RENZAPRIDE | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL156977 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL350221 | OXITRIPTAN | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 158.49 | nM | 6.80 |