Assay Detail
Binding
CHEMBL875083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]GR-65630 radioligand.
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094132) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
The binding of arylguanidines at 5-HT(3) serotonin receptors: a structure-affinity investigation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 6.81 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13535 | — | — | 1 | 9.15 |
| CHEMBL40929 | — | — | 1 | 8.74 |
| CHEMBL275293 | — | — | 1 | 8.57 |
| CHEMBL40999 | — | — | 1 | 8.51 |
| CHEMBL288055 | — | — | 1 | 8.30 |
| CHEMBL41433 | — | — | 1 | 7.92 |
| CHEMBL43078 | — | — | 1 | 7.85 |
| CHEMBL13790 | — | — | 1 | 7.75 |
| CHEMBL40567 | — | — | 1 | 7.75 |
| CHEMBL13823 | — | — | 1 | 7.50 |
| CHEMBL43298 | — | — | 1 | 7.44 |
| CHEMBL42752 | — | — | 1 | 7.21 |
| CHEMBL41853 | — | — | 1 | 6.72 |
| CHEMBL840 | 4-CHLOROPHENYLBIGUANIDE | — | 1 | 6.68 |
| CHEMBL42538 | — | — | 1 | 6.66 |
| CHEMBL40190 | — | — | 1 | 6.65 |
| CHEMBL43961 | — | — | 1 | 6.64 |
| CHEMBL44100 | — | — | 1 | 6.56 |
| CHEMBL41040 | — | — | 1 | 6.49 |
| CHEMBL43415 | — | — | 1 | 6.36 |
| CHEMBL289594 | — | — | 1 | 6.35 |
| CHEMBL289319 | — | — | 1 | 6.11 |
| CHEMBL291064 | — | — | 1 | 6.05 |
| CHEMBL297076 | — | — | 1 | 6.00 |
| CHEMBL40488 | — | — | 1 | 5.92 |
| CHEMBL13791 | PHENYL BIGUANIDE | — | 1 | 5.92 |
| CHEMBL40459 | — | — | 1 | 5.90 |
| CHEMBL43459 | — | — | 1 | 5.80 |
| CHEMBL14047 | PHENYLGUANIDINE | — | 1 | 5.63 |
| CHEMBL44236 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13535 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL40929 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL275293 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL40999 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL288055 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL41433 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL43078 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL13790 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL40567 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL13823 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL43298 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL42752 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL41853 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL840 | 4-CHLOROPHENYLBIGUANIDE | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL42538 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL40190 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL43961 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL44100 | — | Ki | = | 274.0 | nM | 6.56 |
| CHEMBL41040 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL43415 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL289594 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL289319 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL291064 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL297076 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL40488 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL13791 | PHENYL BIGUANIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL40459 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL43459 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL14047 | PHENYLGUANIDINE | Ki | = | 2340.0 | nM | 5.63 |
| CHEMBL44236 | — | Ki | = | 2440.0 | nM | 5.61 |
| CHEMBL42751 | — | Ki | = | 2710.0 | nM | 5.57 |
| CHEMBL41272 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL295000 | — | Ki | = | 6520.0 | nM | 5.19 |
| CHEMBL40647 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL290199 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL14435 | — | Ki | > | 10000.0 | nM | - |