Assay Detail
Binding
CHEMBL875417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of 5-LO by measuring the reduction of leukotriene B4 (LTB4) in intact basophilic rat leukemia cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.58 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16828 | — | — | 1 | 6.04 |
| CHEMBL8562 | — | — | 1 | 5.60 |
| CHEMBL12594 | E-5110 | — | 1 | 5.37 |
| CHEMBL2079592 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16828 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL8562 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL12594 | E-5110 | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2079592 | — | IC50 | = | 5000.0 | nM | 5.30 |