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Assay Detail

CHEMBL875520

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to A1 adenosine receptor in rat fat cell membrane
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A1 (CHEMBL318)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.
Shamim MT, Ukena D, Padgett WL, Daly JW.
J Med Chem (1989) 32 : 1231 -1237
PubMed 2724296 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.89 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL9069 1 6.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL9069 Ki = 130.0 nM 6.89