Assay Detail
Binding
CHEMBL875559
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In vitro inhibitory activity against bovine acetylcholinesterase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.24 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | — | 1 | 8.94 |
| CHEMBL143812 | — | — | 1 | 8.89 |
| CHEMBL4524111 | — | — | 1 | 8.46 |
| CHEMBL322343 | — | — | 1 | 8.35 |
| CHEMBL341658 | — | — | 1 | 8.17 |
| CHEMBL325338 | — | — | 1 | 7.56 |
| CHEMBL322281 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | IC50 | = | 1.148 | nM | 8.94 |
| CHEMBL143812 | — | IC50 | = | 1.288 | nM | 8.89 |
| CHEMBL4524111 | — | IC50 | = | 3.467 | nM | 8.46 |
| CHEMBL322343 | — | IC50 | = | 4.467 | nM | 8.35 |
| CHEMBL341658 | — | IC50 | = | 6.761 | nM | 8.17 |
| CHEMBL325338 | — | IC50 | = | 27.54 | nM | 7.56 |
| CHEMBL322281 | — | IC50 | = | 46.77 | nM | 7.33 |