Assay Detail
Binding
CHEMBL875680
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Inhibitory activity against human recombinant Caspase-3 enzyme
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.33 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23226 | — | — | 1 | 7.52 |
| CHEMBL1794026 | — | — | 1 | 7.16 |
| CHEMBL23493 | — | — | 1 | 7.00 |
| CHEMBL23299 | — | — | 1 | 7.00 |
| CHEMBL23816 | — | — | 1 | 7.00 |
| CHEMBL282508 | — | — | 1 | 6.82 |
| CHEMBL26108 | — | — | 1 | 6.70 |
| CHEMBL22597 | — | — | 1 | 6.40 |
| CHEMBL22412 | — | — | 1 | 6.22 |
| CHEMBL23453 | — | — | 1 | 5.96 |
| CHEMBL280373 | — | — | 1 | 5.85 |
| CHEMBL25268 | — | — | 1 | 5.80 |
| CHEMBL23225 | — | — | 1 | 5.72 |
| CHEMBL280927 | — | — | 1 | 5.64 |
| CHEMBL1794025 | — | — | 1 | 5.58 |
| CHEMBL280878 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23226 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1794026 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL23493 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL23299 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL23816 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL282508 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL26108 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL22597 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL22412 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL23453 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL280373 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL25268 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL23225 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL280927 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1794025 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL280878 | — | IC50 | = | 14000.0 | nM | 4.85 |