Assay Detail
Binding
CHEMBL875702
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Concentration required for 50% Inhibition against Cholesteryl ester transfer protein in presence of human serum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.78 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338700 | — | — | 1 | 5.31 |
| CHEMBL340310 | — | — | 1 | 4.70 |
| CHEMBL125791 | — | — | 1 | 4.34 |
| CHEMBL125473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338700 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL340310 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL125791 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL125473 | — | IC50 | > | 200000.0 | nM | - |