Assay Detail
Binding
CHEMBL875703
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Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine protease
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.89 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326093 | — | — | 1 | 9.30 |
| CHEMBL113706 | — | — | 1 | 8.74 |
| CHEMBL117928 | — | — | 1 | 8.60 |
| CHEMBL332025 | — | — | 1 | 8.30 |
| CHEMBL116041 | — | — | 1 | 8.22 |
| CHEMBL323637 | — | — | 1 | 8.12 |
| CHEMBL114410 | — | — | 1 | 8.12 |
| CHEMBL326342 | — | — | 1 | 7.46 |
| CHEMBL323638 | — | — | 1 | 6.40 |
| CHEMBL115822 | — | — | 1 | 5.60 |
| CHEMBL421054 | — | — | 1 | - |
| CHEMBL323704 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326093 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL113706 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL117928 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL332025 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL116041 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL323637 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL114410 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL326342 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL323638 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL115822 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL421054 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL323704 | — | IC50 | > | 2500.0 | nM | - |