Assay Detail
Binding
CHEMBL875789
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In vitro inhibitory activity against human AchE (Acetylcholinesterase)
22
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 8-carbaphysostigmine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.64 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34222 | — | — | 3 | 7.70 |
| CHEMBL416586 | — | — | 3 | 7.44 |
| CHEMBL286690 | — | — | 1 | 7.16 |
| CHEMBL284938 | — | — | 1 | 7.11 |
| CHEMBL433041 | EPTASTIGMINE | 2.0 | 1 | 6.96 |
| CHEMBL32966 | — | — | 1 | 6.94 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 6.89 |
| CHEMBL32964 | — | — | 1 | 6.81 |
| CHEMBL33161 | — | — | 1 | 6.75 |
| CHEMBL284369 | — | — | 1 | 6.68 |
| CHEMBL287691 | — | — | 1 | 6.60 |
| CHEMBL32543 | — | — | 2 | 6.29 |
| CHEMBL33098 | — | — | 1 | 6.20 |
| CHEMBL33727 | — | — | 1 | 5.97 |
| CHEMBL33173 | — | — | 1 | 5.88 |
| CHEMBL32653 | — | — | 1 | 5.66 |
| CHEMBL34002 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34222 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL416586 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL34222 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL416586 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL286690 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL284938 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL433041 | EPTASTIGMINE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL32966 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL32964 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL33161 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL416586 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL284369 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL34222 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL287691 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL32543 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL32543 | — | IC50 | = | 546.0 | nM | 6.26 |
| CHEMBL33098 | — | IC50 | = | 629.0 | nM | 6.20 |
| CHEMBL33727 | — | IC50 | = | 1076.0 | nM | 5.97 |
| CHEMBL33173 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL32653 | — | IC50 | = | 2192.0 | nM | 5.66 |
| CHEMBL34002 | — | IC50 | = | 12487.0 | nM | 4.90 |