Assay Detail
Binding
CHEMBL875909
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Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.90 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 9.40 |
| CHEMBL312448 | XYLOMETAZOLINE | 3.0 | 1 | 9.15 |
| CHEMBL308042 | — | — | 1 | 8.96 |
| CHEMBL70409 | — | — | 1 | 8.17 |
| CHEMBL73281 | — | — | 1 | 7.89 |
| CHEMBL72178 | — | — | 1 | 7.14 |
| CHEMBL307408 | — | — | 1 | 7.13 |
| CHEMBL72107 | — | — | 1 | 7.07 |
| CHEMBL308727 | — | — | 1 | 6.98 |
| CHEMBL73670 | — | — | 1 | 6.47 |
| CHEMBL309162 | — | — | 1 | 5.99 |
| CHEMBL303441 | — | — | 1 | 5.96 |
| CHEMBL72158 | — | — | 1 | 5.87 |
| CHEMBL72167 | — | — | 1 | 5.72 |
| CHEMBL71033 | — | — | 1 | 5.66 |
| CHEMBL73190 | — | — | 1 | 5.62 |
| CHEMBL73943 | — | — | 1 | 5.60 |
| CHEMBL309976 | — | — | 1 | 5.36 |
| CHEMBL770 | TOLAZOLINE | 4.0 | 1 | - |
| CHEMBL71751 | — | — | 1 | - |
| CHEMBL56898 | — | — | 1 | - |
| CHEMBL450281 | — | — | 1 | - |
| CHEMBL306940 | — | — | 1 | - |
| CHEMBL73429 | — | — | 1 | - |
| CHEMBL306699 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL312448 | XYLOMETAZOLINE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL308042 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL70409 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL73281 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL72178 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL307408 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL72107 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL308727 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL73670 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL309162 | — | Ki | = | 1035.0 | nM | 5.99 |
| CHEMBL303441 | — | Ki | = | 1095.0 | nM | 5.96 |
| CHEMBL72158 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL72167 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL71033 | — | Ki | = | 2210.0 | nM | 5.66 |
| CHEMBL73190 | — | Ki | = | 2375.0 | nM | 5.62 |
| CHEMBL73943 | — | Ki | = | 2520.0 | nM | 5.60 |
| CHEMBL309976 | — | Ki | = | 4390.0 | nM | 5.36 |
| CHEMBL770 | TOLAZOLINE | Ki | > | 10000.0 | nM | - |
| CHEMBL71751 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL56898 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL450281 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL306940 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL73429 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL306699 | — | Ki | > | 5000.0 | nM | - |