Assay Detail
Functional
CHEMBL875931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 7.57 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414185 | — | — | 1 | 9.40 |
| CHEMBL155326 | — | — | 1 | 8.79 |
| CHEMBL155327 | — | — | 1 | 8.43 |
| CHEMBL346380 | — | — | 1 | 8.24 |
| CHEMBL152155 | — | — | 1 | 8.20 |
| CHEMBL154298 | — | — | 1 | 7.52 |
| CHEMBL152725 | — | — | 1 | 7.33 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 7.20 |
| CHEMBL434074 | — | — | 1 | 7.16 |
| CHEMBL156661 | — | — | 1 | 7.11 |
| CHEMBL347268 | — | — | 1 | 7.02 |
| CHEMBL152693 | — | — | 1 | 6.95 |
| CHEMBL349082 | — | — | 1 | 6.47 |
| CHEMBL358685 | — | — | 1 | 6.17 |
| CHEMBL351542 | — | — | 1 | - |
| CHEMBL351543 | — | — | 1 | - |
| CHEMBL347920 | — | — | 1 | - |
| CHEMBL154170 | — | — | 1 | - |
| CHEMBL350906 | — | — | 1 | - |
| CHEMBL156950 | — | — | 1 | - |
| CHEMBL156893 | — | — | 1 | - |
| CHEMBL154346 | — | — | 1 | - |
| CHEMBL346465 | — | — | 1 | - |
| CHEMBL152154 | — | — | 1 | - |
| CHEMBL352225 | — | — | 1 | - |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | - |
| CHEMBL356195 | — | — | 1 | - |
| CHEMBL439822 | — | — | 1 | - |
| CHEMBL117381 | — | — | 1 | - |
| CHEMBL761 | NAPHAZOLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414185 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL155326 | — | EC50 | = | 1.622 | nM | 8.79 |
| CHEMBL155327 | — | EC50 | = | 3.715 | nM | 8.43 |
| CHEMBL346380 | — | EC50 | = | 5.754 | nM | 8.24 |
| CHEMBL152155 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL154298 | — | EC50 | = | 30.2 | nM | 7.52 |
| CHEMBL152725 | — | EC50 | = | 46.77 | nM | 7.33 |
| CHEMBL13852 | CIRAZOLINE | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL434074 | — | EC50 | = | 69.18 | nM | 7.16 |
| CHEMBL156661 | — | EC50 | = | 77.62 | nM | 7.11 |
| CHEMBL347268 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL152693 | — | EC50 | = | 112.2 | nM | 6.95 |
| CHEMBL349082 | — | EC50 | = | 338.84 | nM | 6.47 |
| CHEMBL358685 | — | EC50 | = | 676.08 | nM | 6.17 |
| CHEMBL154023 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL351542 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL351543 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL347920 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL154170 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL350906 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL156950 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL156893 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL154346 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL346465 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL152154 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL352225 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL762 | OXYMETAZOLINE | EC50 | < | 5011.87 | nM | - |
| CHEMBL356195 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL439822 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL117381 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL761 | NAPHAZOLINE | EC50 | < | 5011.87 | nM | - |