Assay Detail
Functional
CHEMBL876000
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against glutamate stimulated accumulation of cyclic GMP in neonatal rat cerebral slices
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.69 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31741 | — | — | 1 | 7.51 |
| CHEMBL289832 | LICOSTINEL | 2.0 | 1 | 6.74 |
| CHEMBL419045 | GAVESTINEL SODIUM | — | 1 | 6.58 |
| CHEMBL180427 | — | — | 1 | 6.55 |
| CHEMBL425691 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31741 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL289832 | LICOSTINEL | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL419045 | GAVESTINEL SODIUM | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL180427 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL425691 | — | IC50 | = | 840.0 | nM | 6.08 |