Assay Detail
Functional
CHEMBL876077
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Effective concentration that reduces HIV-induced cytopathic effect by 50% was determined by MTT assay.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-c113 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and anti-HIV evaluation of D4T and D4T 5'-monophosphate prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.08 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.22 |
| CHEMBL166784 | — | — | 1 | 8.05 |
| CHEMBL352398 | — | — | 1 | 7.70 |
| CHEMBL353179 | — | — | 1 | 7.70 |
| CHEMBL440551 | — | — | 1 | 7.40 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 7.10 |
| CHEMBL166614 | — | — | 1 | 7.00 |
| CHEMBL170331 | — | — | 1 | 7.00 |
| CHEMBL170006 | — | — | 1 | 6.92 |
| CHEMBL424540 | — | — | 1 | 6.52 |
| CHEMBL354162 | — | — | 1 | 6.00 |
| CHEMBL168943 | — | — | 1 | 5.37 |
| CHEMBL168236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL166784 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL352398 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL353179 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL440551 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL991 | STAVUDINE | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL166614 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL170331 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL170006 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL424540 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL354162 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL168943 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL168236 | — | EC50 | > | 20000.0 | nM | - |