Assay Detail
Functional
CHEMBL876256
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Tested for in vitro drug concentration which results in 50% survival of uninfected untreated control CEM cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral (HIV-1, HBV) activities of 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidine diastereomers. Potential prodrugs to 3'-fluoro-3'-deoxythymidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.78 | 5.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118427 | — | — | 1 | 5.76 |
| CHEMBL116767 | — | — | 1 | 5.01 |
| CHEMBL121850 | — | — | 1 | 4.91 |
| CHEMBL119448 | — | — | 1 | 4.24 |
| CHEMBL116319 | — | — | 1 | 4.00 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL119051 | — | — | 1 | - |
| CHEMBL334183 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118427 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL116767 | — | IC50 | = | 9720.0 | nM | 5.01 |
| CHEMBL121850 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL119448 | — | IC50 | = | 57300.0 | nM | 4.24 |
| CHEMBL116319 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 500000.0 | nM | - |
| CHEMBL119051 | — | IC50 | > | 800000.0 | nM | - |
| CHEMBL334183 | — | IC50 | > | 800000.0 | nM | - |