Assay Detail
Binding
CHEMBL876361
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In vitro binding affinity for human 5-hydroxytryptamine 1A receptor
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.88 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361303 | — | — | 1 | 7.96 |
| CHEMBL361061 | — | — | 1 | 7.92 |
| CHEMBL101690 | — | — | 1 | 7.66 |
| CHEMBL445651 | — | — | 1 | 6.80 |
| CHEMBL187952 | — | — | 3 | 6.62 |
| CHEMBL365405 | — | — | 1 | 6.51 |
| CHEMBL184994 | — | — | 1 | 6.07 |
| CHEMBL184597 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361303 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL361061 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL101690 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL445651 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL187952 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL187952 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL187952 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL365405 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL184994 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL184597 | — | Ki | = | 870.0 | nM | 6.06 |