Assay Detail
Binding
CHEMBL876375
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Inhibition of [3H]prazosin binding to rat Alpha-1 adrenergic receptor
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.27 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.60 |
| CHEMBL193639 | — | — | 2 | 8.12 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.66 |
| CHEMBL363581 | — | — | 1 | 7.50 |
| CHEMBL435301 | — | — | 1 | 7.46 |
| CHEMBL366164 | — | — | 1 | 7.39 |
| CHEMBL194659 | — | — | 1 | 7.15 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.13 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.06 |
| CHEMBL329566 | — | — | 1 | 6.97 |
| CHEMBL364270 | — | — | 1 | 6.64 |
| CHEMBL193435 | — | — | 1 | 6.63 |
| CHEMBL195706 | — | — | 1 | 6.47 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL193639 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL193639 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL42 | CLOZAPINE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL363581 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL435301 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL366164 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL194659 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL6437 | MIANSERIN | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL715 | OLANZAPINE | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL329566 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL364270 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL193435 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL195706 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL654 | MIRTAZAPINE | Ki | = | 608.0 | nM | 6.22 |