Assay Detail
Binding
CHEMBL876378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant against rabbit liver carboxylesterase using o-NPA (nitrophenyl acetate)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.73 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193228 | — | — | 1 | 8.39 |
| CHEMBL362996 | — | — | 1 | 8.21 |
| CHEMBL192139 | — | — | 1 | 8.02 |
| CHEMBL191847 | — | — | 1 | 7.92 |
| CHEMBL192180 | — | — | 1 | 7.62 |
| CHEMBL189886 | BENZIL | — | 1 | 6.99 |
| CHEMBL193140 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193228 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL362996 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL192139 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL191847 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL192180 | — | Ki | = | 23.9 | nM | 7.62 |
| CHEMBL189886 | BENZIL | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL193140 | — | Ki | = | 108.0 | nM | 6.97 |