Assay Detail
Binding
CHEMBL876385
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Inhibitory potency against human cloned Carbonic anhydrase I expressed in Escherichia coli strain BL21
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.74 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360097 | — | — | 1 | 8.15 |
| CHEMBL183705 | — | — | 1 | 8.12 |
| CHEMBL183450 | — | — | 1 | 8.10 |
| CHEMBL183442 | — | — | 1 | 8.09 |
| CHEMBL183775 | — | — | 1 | 8.03 |
| CHEMBL179897 | — | — | 1 | 8.02 |
| CHEMBL180943 | — | — | 1 | 8.02 |
| CHEMBL182634 | — | — | 1 | 7.85 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL360041 | — | — | 1 | 6.43 |
| CHEMBL182476 | — | — | 1 | 6.42 |
| CHEMBL182637 | — | — | 1 | 6.26 |
| CHEMBL183763 | — | — | 1 | 6.19 |
| CHEMBL182523 | — | — | 1 | 6.12 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL182185 | — | — | 1 | 6.09 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL265674 | — | — | 1 | 5.07 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 4.55 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360097 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL183705 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL183450 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL183442 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL183775 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL179897 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL180943 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL182634 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL360041 | — | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL182476 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL182637 | — | Ki | = | 549.0 | nM | 6.26 |
| CHEMBL183763 | — | Ki | = | 644.0 | nM | 6.19 |
| CHEMBL182523 | — | Ki | = | 752.0 | nM | 6.12 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL182185 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL265674 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 50000.0 | nM | 4.30 |