Assay Detail
Functional
CHEMBL876396
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Inhibition of human epidermoid carcinoma xenograft (A431) tumor growth
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.20 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414220 | — | — | 1 | 7.48 |
| CHEMBL285063 | — | — | 1 | 7.02 |
| CHEMBL94066 | — | — | 1 | 6.89 |
| CHEMBL93049 | — | — | 1 | 6.51 |
| CHEMBL94123 | — | — | 1 | 5.97 |
| CHEMBL92086 | — | — | 1 | 5.88 |
| CHEMBL91748 | — | — | 1 | 5.68 |
| CHEMBL93464 | — | — | 1 | 5.23 |
| CHEMBL329642 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414220 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL285063 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL94066 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL93049 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL94123 | — | IC50 | = | 1079.0 | nM | 5.97 |
| CHEMBL92086 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL91748 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL93464 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL329642 | — | IC50 | = | 6610.0 | nM | 5.18 |