Assay Detail
Binding
CHEMBL876476
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Inhibitory activity against Human Recombinant Adenosine Kinase
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Adenosine kinase inhibitors. 4. 6,8-Disubstituted purine nucleoside derivatives. Synthesis, conformation, and enzyme inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.55 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100421 | — | — | 1 | 9.30 |
| CHEMBL328826 | — | — | 1 | 9.00 |
| CHEMBL364496 | — | — | 1 | 7.72 |
| CHEMBL189105 | — | — | 1 | 7.29 |
| CHEMBL362987 | — | — | 1 | 7.22 |
| CHEMBL192504 | — | — | 1 | 7.05 |
| CHEMBL192903 | — | — | 1 | 6.82 |
| CHEMBL302376 | — | — | 1 | 6.77 |
| CHEMBL193065 | — | — | 1 | 6.70 |
| CHEMBL371350 | — | — | 1 | 6.64 |
| CHEMBL189106 | — | — | 1 | 6.52 |
| CHEMBL193265 | — | — | 1 | 6.32 |
| CHEMBL191760 | — | — | 1 | 6.30 |
| CHEMBL189781 | — | — | 1 | 6.00 |
| CHEMBL193175 | — | — | 1 | 6.00 |
| CHEMBL192727 | — | — | 1 | 6.00 |
| CHEMBL373129 | — | — | 1 | 5.70 |
| CHEMBL363354 | — | — | 1 | 5.54 |
| CHEMBL192259 | — | — | 1 | 5.44 |
| CHEMBL364457 | — | — | 1 | 5.35 |
| CHEMBL363215 | — | — | 1 | 5.16 |
| CHEMBL193246 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100421 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL328826 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL364496 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL189105 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL362987 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL192504 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL192903 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL302376 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL193065 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL371350 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL189106 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL193265 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL191760 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL189781 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL193175 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL192727 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL373129 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL363354 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL192259 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL364457 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL363215 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL193246 | — | IC50 | = | 7100.0 | nM | 5.15 |