Assay Detail
Binding
CHEMBL876479
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.65 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363063 | — | — | 1 | 6.05 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.69 |
| CHEMBL364123 | — | — | 1 | 5.66 |
| CHEMBL189189 | — | — | 1 | 5.57 |
| CHEMBL186106 | — | — | 1 | 5.48 |
| CHEMBL363956 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363063 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL364123 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL189189 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL186106 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL363956 | — | IC50 | = | 3760.0 | nM | 5.42 |