Assay Detail
Binding
CHEMBL876539
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Tested for Beta-2 adrenergic receptor selectivity in canine lung tissue in anesthetized dogs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Beta-2 adrenergic receptor (CHEMBL2289) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.34 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 7.77 |
| CHEMBL98773 | — | — | 1 | 5.92 |
| CHEMBL95966 | — | — | 1 | 5.36 |
| CHEMBL471 | SOTALOL | 4.0 | 1 | 5.28 |
| CHEMBL95754 | — | — | 1 | 5.18 |
| CHEMBL100624 | — | — | 1 | 4.58 |
| CHEMBL95727 | — | — | 1 | 4.34 |
| CHEMBL99331 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL98773 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL95966 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL471 | SOTALOL | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL95754 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL100624 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL95727 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL99331 | — | IC50 | = | 49300.0 | nM | 4.31 |