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Compound Detail

CHEMBL95727

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COCCc1ccc(OCC(O)CNCc2ccc(NS(C)(=O)=O)cc2)cc1

Basic Information

ChEMBL ID CHEMBL95727
Phase Preclinical
Structure Type MOL
InChI Key JBIIIJUBMKGJTB-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

408.5
MW (Da)
1.78
ALogP
6
HBA
3
HBD
96.9
PSA (Ų)
0.50
QED
0
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H28N2O5S
MW 408.52
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -1.00

Activity Summary

IC50 3 meas. best 5.14

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL213
IC50 5.14 5.14 7300.0 1
Adrenergic receptor beta
CHEMBL2094118
IC50 4.59 4.59 25800.0 1
Beta-2 adrenergic receptor
CHEMBL2289
IC50 4.34 4.34 46000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1976812 10.1021/jm00172a033 Canis familiaris 2
1976812 10.1021/jm00172a033 Adrenergic receptor beta 1
1976812 10.1021/jm00172a033 Beta-1 adrenergic receptor 1
1976812 10.1021/jm00172a033 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine