Assay Detail
Binding
CHEMBL647668
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Tested for Beta adrenergic receptor binding inhibition from canine ventricular tissue, using [3H]dihydroalprenolol as the radioligand in anesthetized dogs
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.24 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95784 | — | — | 1 | 6.82 |
| CHEMBL317163 | — | — | 1 | 6.38 |
| CHEMBL98773 | — | — | 1 | 6.11 |
| CHEMBL95966 | — | — | 1 | 6.00 |
| CHEMBL95754 | — | — | 1 | 5.64 |
| CHEMBL98979 | — | — | 1 | 5.54 |
| CHEMBL95911 | — | — | 1 | 5.54 |
| CHEMBL318131 | — | — | 1 | 5.41 |
| CHEMBL471 | SOTALOL | 4.0 | 1 | 5.14 |
| CHEMBL99513 | — | — | 1 | 5.08 |
| CHEMBL99815 | — | — | 1 | 4.91 |
| CHEMBL99532 | — | — | 1 | 4.91 |
| CHEMBL98575 | — | — | 1 | 4.80 |
| CHEMBL317274 | — | — | 1 | 4.80 |
| CHEMBL99331 | — | — | 1 | 4.80 |
| CHEMBL95727 | — | — | 1 | 4.59 |
| CHEMBL99652 | — | — | 1 | 4.51 |
| CHEMBL95894 | — | — | 1 | 4.36 |
| CHEMBL99188 | — | — | 1 | 4.21 |
| CHEMBL99179 | — | — | 1 | - |
| CHEMBL95985 | — | — | 1 | - |
| CHEMBL99391 | — | — | 1 | - |
| CHEMBL95795 | — | — | 1 | - |
| CHEMBL99814 | — | — | 1 | - |
| CHEMBL95804 | SEMATILIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95784 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL317163 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL98773 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL95966 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL95754 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL98979 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL95911 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL318131 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL471 | SOTALOL | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL99513 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL99815 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL99532 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL98575 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL317274 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL99331 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL95727 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL99652 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL95894 | — | IC50 | = | 43800.0 | nM | 4.36 |
| CHEMBL99188 | — | IC50 | = | 61400.0 | nM | 4.21 |
| CHEMBL99179 | — | IC50 | = | 192000.0 | nM | - |
| CHEMBL95985 | — | IC50 | = | 360000.0 | nM | - |
| CHEMBL99391 | — | IC50 | = | 109000.0 | nM | - |
| CHEMBL95795 | — | IC50 | = | 293000.0 | nM | - |
| CHEMBL99814 | — | IC50 | = | 227000.0 | nM | - |
| CHEMBL95804 | SEMATILIDE | IC50 | = | 7000000.0 | nM | - |