Assay Detail
Binding
CHEMBL650688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for Beta-1 adrenergic receptor selectivity in canine cardiac tissue in anesthetized dogs
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.47 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 7.75 |
| CHEMBL98773 | — | — | 1 | 6.10 |
| CHEMBL1193886 | ERSENTILIDE | 2.0 | 2 | 5.80 |
| CHEMBL95966 | — | — | 1 | 5.62 |
| CHEMBL95754 | — | — | 1 | 5.48 |
| CHEMBL95727 | — | — | 1 | 5.14 |
| CHEMBL471 | SOTALOL | 4.0 | 1 | 5.05 |
| CHEMBL99331 | — | — | 1 | 4.72 |
| CHEMBL100624 | — | — | 1 | 4.48 |
| CHEMBL1192069 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL98773 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1193886 | ERSENTILIDE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL95966 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1193886 | ERSENTILIDE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL95754 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL95727 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL471 | SOTALOL | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL99331 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL100624 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL1192069 | — | IC50 | = | 37500.0 | nM | 4.43 |