Assay Detail
Binding
CHEMBL876568
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The compound was tested for binding affinity on [3H]- prazosin as specific ligand on alpha-1 adrenergic receptor cells in rat cerebral cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.13 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.13 |
| CHEMBL301726 | — | — | 1 | 7.61 |
| CHEMBL49851 | — | — | 1 | 7.26 |
| CHEMBL301078 | — | — | 1 | 7.13 |
| CHEMBL51074 | — | — | 1 | 6.89 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL301726 | — | Ki | = | 24.6 | nM | 7.61 |
| CHEMBL49851 | — | Ki | = | 54.6 | nM | 7.26 |
| CHEMBL301078 | — | Ki | = | 73.3 | nM | 7.13 |
| CHEMBL51074 | — | Ki | = | 129.2 | nM | 6.89 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 18000.0 | nM | 4.75 |