Assay Detail
Binding
CHEMBL876575
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In vitro binding affinity towards Alpha-1 adrenergic receptor was determined by the displacement of [3H]prazosin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.29 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421027 | — | — | 1 | 9.72 |
| CHEMBL104229 | — | — | 1 | 9.05 |
| CHEMBL322915 | — | — | 1 | 8.55 |
| CHEMBL318604 | — | — | 1 | 8.44 |
| CHEMBL105204 | — | — | 1 | 8.39 |
| CHEMBL104144 | — | — | 1 | 8.33 |
| CHEMBL105390 | — | — | 1 | 7.52 |
| CHEMBL318738 | — | — | 1 | 7.48 |
| CHEMBL442391 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421027 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL104229 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL322915 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL318604 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL105204 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL104144 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL105390 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL318738 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL442391 | — | Ki | = | 78.0 | nM | 7.11 |