Assay Detail
Functional
CHEMBL876652
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In vitro antitumor activity was assessed from rate of cell growth of CCRF/CEM cell line
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.52 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305747 | — | — | 1 | 8.64 |
| CHEMBL34412 | LOMETREXOL | 2.0 | 2 | 7.82 |
| CHEMBL67297 | — | — | 1 | 7.57 |
| CHEMBL13624 | — | — | 1 | 7.23 |
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | — | 1 | 6.88 |
| CHEMBL13659 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305747 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL34412 | LOMETREXOL | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL34412 | LOMETREXOL | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL67297 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL13624 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL13659 | — | IC50 | = | 198.0 | nM | 6.70 |