Assay Detail
Functional
CHEMBL876745
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Effective concentration at Alpha-2C adrenergic receptor from CHO-C4 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO-C4 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.87 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 8.47 |
| CHEMBL308570 | — | — | 1 | 8.18 |
| CHEMBL432155 | — | — | 1 | 6.96 |
| CHEMBL75257 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL844 | BRIMONIDINE | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL308570 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL432155 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL75257 | — | EC50 | > | 5000.0 | nM | - |