Assay Detail
Binding
CHEMBL876749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit binding of [3H]PRAZ to alpha-1 adrenergic receptor in rat brain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.31 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 9.74 |
| CHEMBL303313 | — | — | 1 | 9.35 |
| CHEMBL64875 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64249 | CLOROTEPINE | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL303313 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL64875 | — | IC50 | = | 1.4 | nM | 8.85 |