Assay Detail
Binding
CHEMBL876751
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Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in rat adrenal cortex
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
(6-oxo-3-pyridazinyl)-benzimidazoles as potent angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.47 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2079789 | — | — | 1 | 8.80 |
| CHEMBL2079788 | — | — | 1 | 8.77 |
| CHEMBL24266 | — | — | 1 | 8.74 |
| CHEMBL24224 | — | — | 1 | 8.74 |
| CHEMBL2079792 | — | — | 1 | 8.55 |
| CHEMBL2079790 | — | — | 1 | 8.54 |
| CHEMBL284704 | — | — | 1 | 8.49 |
| CHEMBL2079785 | — | — | 1 | 8.47 |
| CHEMBL2079786 | — | — | 1 | 8.44 |
| CHEMBL2079791 | — | — | 1 | 8.44 |
| CHEMBL26389 | — | — | 1 | 8.36 |
| CHEMBL2079787 | — | — | 1 | 8.33 |
| CHEMBL26437 | — | — | 1 | 8.30 |
| CHEMBL25989 | — | — | 1 | 8.20 |
| CHEMBL284703 | — | — | 1 | 8.19 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2079789 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2079788 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL24266 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL24224 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2079792 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2079790 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL284704 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2079785 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL2079786 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL2079791 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL26389 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2079787 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL26437 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL25989 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL284703 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL191 | LOSARTAN | IC50 | = | 8.2 | nM | 8.09 |