Assay Detail
Functional
CHEMBL876779
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Concentration required for 50% growth inhibition of human LoVo cancer cell lines after 3 days of culture
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.66 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL369587 | — | — | 1 | 8.30 |
| CHEMBL368047 | — | — | 1 | 8.00 |
| CHEMBL178993 | — | — | 1 | 8.00 |
| CHEMBL175806 | — | — | 1 | 8.00 |
| CHEMBL175452 | — | — | 1 | 7.89 |
| CHEMBL360322 | — | — | 1 | 7.77 |
| CHEMBL175947 | — | — | 1 | 7.75 |
| CHEMBL175946 | — | — | 1 | 7.75 |
| CHEMBL176316 | — | — | 1 | 7.72 |
| CHEMBL433564 | — | — | 1 | 7.48 |
| CHEMBL175716 | — | — | 1 | 7.05 |
| CHEMBL177836 | — | — | 1 | 7.00 |
| CHEMBL180496 | — | — | 1 | 6.61 |
| CHEMBL369515 | — | — | 1 | 6.47 |
| CHEMBL434923 | — | — | 1 | 6.03 |
| CHEMBL178933 | — | — | 1 | 5.97 |
| CHEMBL175719 | — | — | 1 | 5.81 |
| CHEMBL175921 | — | — | 1 | 5.63 |
| CHEMBL360496 | — | — | 1 | 5.56 |
| CHEMBL175769 | — | — | 1 | 5.52 |
| CHEMBL175981 | — | — | 1 | 5.45 |
| CHEMBL366906 | — | — | 1 | 5.41 |
| CHEMBL367124 | — | — | 1 | 5.32 |
| CHEMBL366970 | — | — | 1 | 5.08 |
| CHEMBL426228 | — | — | 1 | 5.02 |
| CHEMBL427124 | — | — | 1 | - |
| CHEMBL262795 | — | — | 1 | - |
| CHEMBL360685 | — | — | 1 | - |
| CHEMBL367694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL369587 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL368047 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL178993 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL175806 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL175452 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL360322 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL175947 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL175946 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL176316 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL433564 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL175716 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL177836 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL180496 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL369515 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL434923 | — | IC50 | = | 931.0 | nM | 6.03 |
| CHEMBL178933 | — | IC50 | = | 1059.0 | nM | 5.97 |
| CHEMBL175719 | — | IC50 | = | 1557.0 | nM | 5.81 |
| CHEMBL175921 | — | IC50 | = | 2367.0 | nM | 5.63 |
| CHEMBL360496 | — | IC50 | = | 2772.0 | nM | 5.56 |
| CHEMBL175769 | — | IC50 | = | 2997.0 | nM | 5.52 |
| CHEMBL175981 | — | IC50 | = | 3542.0 | nM | 5.45 |
| CHEMBL366906 | — | IC50 | = | 3853.0 | nM | 5.41 |
| CHEMBL367124 | — | IC50 | = | 4836.0 | nM | 5.32 |
| CHEMBL366970 | — | IC50 | = | 8392.0 | nM | 5.08 |
| CHEMBL426228 | — | IC50 | = | 9570.0 | nM | 5.02 |
| CHEMBL427124 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL262795 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL360685 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL367694 | — | IC50 | > | 10000.0 | nM | - |