Assay Detail
Functional
CHEMBL876781
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Inhibitory constant against Zn-Cam (Methanosarcina thermophila)
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Methanosarcina thermophila |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 4.17 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200739 | HYDROGEN SULFIDE | — | 1 | 4.30 |
| CHEMBL355001 | SULFAMIDE | — | 1 | 4.16 |
| CHEMBL185198 | CYNOOXIDE ANION | — | 1 | 4.05 |
| CHEMBL1231821 | HYDROCHLORIC ACID | -1.0 | 1 | - |
| CHEMBL1231461 | BROMIDE | — | 1 | - |
| CHEMBL1233550 | IODIDE | -1.0 | 1 | - |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | - |
| CHEMBL2373151 | OXO(PHENYL)-BORANEDIOL | — | 1 | - |
| CHEMBL84336 | THIOCYANIC ACID | — | 1 | - |
| CHEMBL1362 | FLUORIDE ION | 3.0 | 1 | - |
| CHEMBL186537 | — | — | 1 | - |
| CHEMBL1161632 | BICARBONATE | 3.0 | 2 | - |
| CHEMBL1352 | NITRIC ACID | 3.0 | 1 | - |
| CHEMBL1161681 | NITROUS ACID | 4.0 | 1 | - |
| CHEMBL572964 | SULFURIC ACID | -1.0 | 2 | - |
| CHEMBL68253 | SULFAMATE | — | 1 | - |
| CHEMBL183419 | CYANIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200739 | HYDROGEN SULFIDE | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL355001 | SULFAMIDE | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL185198 | CYNOOXIDE ANION | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL1231821 | HYDROCHLORIC ACID | Ki | > | 200000000.0 | nM | - |
| CHEMBL1231461 | BROMIDE | Ki | = | 160000000.0 | nM | - |
| CHEMBL1233550 | IODIDE | Ki | = | 160000000.0 | nM | - |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 230000.0 | nM | - |
| CHEMBL2373151 | OXO(PHENYL)-BORANEDIOL | Ki | = | 150000.0 | nM | - |
| CHEMBL84336 | THIOCYANIC ACID | Ki | = | 7000000.0 | nM | - |
| CHEMBL183419 | CYANIDE | Ki | = | 680000.0 | nM | - |
| CHEMBL1362 | FLUORIDE ION | Ki | > | 200000000.0 | nM | - |
| CHEMBL1161632 | BICARBONATE | Ki | = | 42000000.0 | nM | - |
| CHEMBL1161632 | BICARBONATE | Ki | = | 6700000.0 | nM | - |
| CHEMBL1352 | NITRIC ACID | Ki | = | 36500000.0 | nM | - |
| CHEMBL1161681 | NITROUS ACID | Ki | = | 6800000.0 | nM | - |
| CHEMBL572964 | SULFURIC ACID | Ki | = | 11700000.0 | nM | - |
| CHEMBL572964 | SULFURIC ACID | Ki | > | 200000000.0 | nM | - |
| CHEMBL68253 | SULFAMATE | Ki | = | 9600000.0 | nM | - |
| CHEMBL186537 | — | Ki | = | 5800000.0 | nM | - |