Assay Detail
Binding
CHEMBL877000
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Inhibition of Butyrylcholinesterase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.00 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.34 |
| CHEMBL179455 | — | — | 1 | 7.20 |
| CHEMBL361165 | — | — | 1 | 5.66 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 4.94 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 45.8 | nM | 7.34 |
| CHEMBL179455 | — | IC50 | = | 63.7 | nM | 7.20 |
| CHEMBL361165 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL11805 | CAPROCTAMINE | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 13200.0 | nM | 4.88 |