Assay Detail
Binding
CHEMBL877123
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Inhibitory concentration against MSK-1
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.74 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188434 | — | — | 1 | 9.30 |
| CHEMBL415770 | — | — | 1 | 8.85 |
| CHEMBL185962 | — | — | 1 | 8.82 |
| CHEMBL188806 | — | — | 1 | 8.70 |
| CHEMBL186317 | — | — | 1 | 8.60 |
| CHEMBL189657 | — | — | 1 | 8.52 |
| CHEMBL426440 | — | — | 1 | 8.52 |
| CHEMBL189231 | — | — | 1 | 8.52 |
| CHEMBL187340 | — | — | 1 | 8.40 |
| CHEMBL188268 | — | — | 1 | 8.40 |
| CHEMBL188433 | — | — | 1 | 8.22 |
| CHEMBL360219 | — | — | 1 | 8.15 |
| CHEMBL364413 | — | — | 1 | 8.10 |
| CHEMBL188620 | — | — | 1 | 8.05 |
| CHEMBL365832 | — | — | 1 | 8.05 |
| CHEMBL363258 | — | — | 1 | 7.89 |
| CHEMBL363054 | — | — | 1 | 7.77 |
| CHEMBL189773 | — | — | 1 | 7.66 |
| CHEMBL188240 | — | — | 1 | 6.76 |
| CHEMBL363990 | — | — | 1 | 6.68 |
| CHEMBL365072 | — | — | 1 | 6.64 |
| CHEMBL191105 | — | — | 1 | 6.21 |
| CHEMBL186343 | — | — | 1 | 6.09 |
| CHEMBL187985 | — | — | 1 | 5.65 |
| CHEMBL371391 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188434 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL415770 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL185962 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL188806 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL186317 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL189657 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL426440 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL189231 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL187340 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL188268 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL188433 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL360219 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL364413 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL188620 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL365832 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL363258 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL363054 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL189773 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL188240 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL363990 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL365072 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL191105 | — | IC50 | = | 617.0 | nM | 6.21 |
| CHEMBL186343 | — | IC50 | = | 813.0 | nM | 6.09 |
| CHEMBL187985 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL371391 | — | IC50 | = | 10000.0 | nM | 5.00 |