Assay Detail
Binding
CHEMBL877277
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In vitro Beta-1 adrenergic receptor affinity in partially purified membrane fractions from canine cardiac tissue using [SH]dihydroalprenolol (4.5 nM)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological studies of N-[4-[2-hydroxy-3-[[2-[4-(1H-imidazol-1- yl)phenoxy]ethyl]amino]propoxy]phenyl]methanesulfonamide, a novel antiarrhythmic agent with class II and class III activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.18 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL545363 | — | — | 1 | 5.77 |
| CHEMBL552615 | — | — | 1 | 5.62 |
| CHEMBL536800 | — | — | 1 | 5.58 |
| CHEMBL11629 | — | — | 1 | 5.55 |
| CHEMBL471 | SOTALOL | 4.0 | 1 | 5.05 |
| CHEMBL11944 | — | — | 1 | 4.75 |
| CHEMBL542544 | — | — | 1 | 4.68 |
| CHEMBL543251 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL545363 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL552615 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL536800 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL11629 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL471 | SOTALOL | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL11944 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL542544 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL543251 | — | IC50 | = | 38000.0 | nM | 4.42 |