Assay Detail
Binding
CHEMBL877293
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Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E
76
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and activity of 2,6,9-trisubstituted purines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 76 | 5.76 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80713 | — | — | 1 | 6.30 |
| CHEMBL90454 | — | — | 1 | 6.30 |
| CHEMBL92288 | — | — | 1 | 6.22 |
| CHEMBL90941 | — | — | 1 | 6.22 |
| CHEMBL93892 | — | — | 1 | 6.22 |
| CHEMBL327684 | — | — | 2 | 6.16 |
| CHEMBL327629 | — | — | 1 | 6.10 |
| CHEMBL90549 | — | — | 1 | 6.00 |
| CHEMBL420571 | — | — | 1 | 6.00 |
| CHEMBL91169 | — | — | 1 | 6.00 |
| CHEMBL90082 | — | — | 1 | 6.00 |
| CHEMBL90628 | — | — | 1 | 6.00 |
| CHEMBL329380 | — | — | 1 | 6.00 |
| CHEMBL264268 | — | — | 1 | 6.00 |
| CHEMBL330026 | — | — | 1 | 6.00 |
| CHEMBL80754 | — | — | 1 | 5.82 |
| CHEMBL91360 | — | — | 1 | 5.70 |
| CHEMBL92544 | — | — | 1 | 5.70 |
| CHEMBL90099 | — | — | 1 | 5.70 |
| CHEMBL314739 | — | — | 1 | 5.70 |
| CHEMBL93626 | — | — | 1 | 5.70 |
| CHEMBL91033 | — | — | 1 | 5.70 |
| CHEMBL316276 | — | — | 1 | 5.70 |
| CHEMBL314378 | — | — | 1 | 5.70 |
| CHEMBL90860 | — | — | 1 | 5.70 |
| CHEMBL88491 | — | — | 1 | 5.70 |
| CHEMBL75924 | — | — | 1 | 5.70 |
| CHEMBL91212 | — | — | 1 | 5.70 |
| CHEMBL312530 | — | — | 1 | 5.70 |
| CHEMBL88813 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80713 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL90454 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL92288 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL90941 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL93892 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL327684 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL327629 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL90628 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL264268 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL330026 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL329380 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL90082 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL91169 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL420571 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL90549 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL80754 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL316276 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL312530 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL88813 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL91360 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL91033 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL75924 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL88491 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL314739 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL92544 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL93626 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL91212 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL90099 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL314378 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL90860 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL90706 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL90300 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL90229 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL328678 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL91378 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL327684 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL328701 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL328027 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL89964 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL327843 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL433154 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL316305 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL328316 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL330000 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL539688 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL90826 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL313226 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL314092 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL330746 | — | IC50 | > | 5000.0 | nM | - |