Assay Detail
Binding
CHEMBL877308
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Inhibitory concentration against Adenosine Kinase (enzyme)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.04 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191309 | — | — | 1 | 8.42 |
| CHEMBL372666 | — | — | 1 | 8.10 |
| CHEMBL193286 | — | — | 1 | 8.05 |
| CHEMBL193253 | — | — | 1 | 7.96 |
| CHEMBL191161 | — | — | 1 | 7.70 |
| CHEMBL189632 | — | — | 1 | 7.52 |
| CHEMBL192887 | — | — | 1 | 7.48 |
| CHEMBL189575 | — | — | 1 | 7.42 |
| CHEMBL191679 | — | — | 1 | 7.35 |
| CHEMBL189161 | — | — | 1 | 7.33 |
| CHEMBL189576 | — | — | 1 | 7.16 |
| CHEMBL302938 | — | — | 1 | 7.04 |
| CHEMBL426992 | — | — | 1 | 6.94 |
| CHEMBL193122 | — | — | 1 | 6.94 |
| CHEMBL371857 | — | — | 1 | 6.75 |
| CHEMBL189480 | — | — | 1 | 6.74 |
| CHEMBL190400 | — | — | 1 | 6.70 |
| CHEMBL150978 | — | — | 1 | 6.46 |
| CHEMBL66338 | — | — | 1 | 6.36 |
| CHEMBL189971 | — | — | 1 | 6.36 |
| CHEMBL193223 | — | — | 1 | 6.33 |
| CHEMBL303499 | — | — | 1 | 6.11 |
| CHEMBL364732 | — | — | 1 | 6.05 |
| CHEMBL192754 | — | — | 1 | 5.65 |
| CHEMBL190144 | — | — | 1 | - |
| CHEMBL191526 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191309 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL372666 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL193286 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL193253 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL191161 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL189632 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL192887 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL189575 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL191679 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL189161 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL189576 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL302938 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL426992 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL193122 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL371857 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL189480 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL190400 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL150978 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL66338 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL189971 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL193223 | — | IC50 | = | 467.0 | nM | 6.33 |
| CHEMBL303499 | — | IC50 | = | 773.0 | nM | 6.11 |
| CHEMBL364732 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL192754 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL190144 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL191526 | — | IC50 | > | 1000.0 | nM | - |