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Assay Detail

CHEMBL877318

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Binding
In vitro inhibitory concentration of compound against factor XIIIa
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Coagulation factor XIII A chain (CHEMBL4530)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3-Substituted imidazo[1,2-d][1,2,4]-thiadiazoles: a novel class of factor XIIIa inhibitors.
Leung-Toung R, Tam TF, Wodzinska JM, Zhao Y, Lowrie J, Simpson CD, Karimian K, Spino M.
J Med Chem (2005) 48 : 2266 -2269
PubMed 15801818 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.15 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL193220 1 7.00
CHEMBL190022 1 6.96
CHEMBL193212 1 6.89
CHEMBL440383 1 6.38
CHEMBL192921 1 6.21
CHEMBL365470 1 6.16
CHEMBL193724 1 6.04
CHEMBL192770 1 5.72
CHEMBL189379 1 5.66
CHEMBL190568 1 5.64
CHEMBL192660 1 4.96
CHEMBL192376 1 -
CHEMBL191254 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL193220 IC50 = 100.0 nM 7.00
CHEMBL190022 IC50 = 110.0 nM 6.96
CHEMBL193212 IC50 = 130.0 nM 6.89
CHEMBL440383 IC50 = 420.0 nM 6.38
CHEMBL192921 IC50 = 620.0 nM 6.21
CHEMBL365470 IC50 = 700.0 nM 6.16
CHEMBL193724 IC50 = 910.0 nM 6.04
CHEMBL192770 IC50 = 1900.0 nM 5.72
CHEMBL189379 IC50 = 2200.0 nM 5.66
CHEMBL190568 IC50 = 2300.0 nM 5.64
CHEMBL192660 IC50 = 11000.0 nM 4.96
CHEMBL192376 IC50 > 100000.0 nM -
CHEMBL191254 IC50 = 170000.0 nM -