Assay Detail
Binding
CHEMBL877456
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Binding affinity towards Alpha-1 adrenergic receptor using 7-methoxy-[3H]-prazosin as radioligand in rat frontal cortex tissue
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.54 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426062 | — | — | 1 | 6.85 |
| CHEMBL361035 | — | — | 1 | 6.80 |
| CHEMBL366304 | — | — | 1 | 6.77 |
| CHEMBL187113 | — | — | 1 | 6.77 |
| CHEMBL186558 | — | — | 1 | 6.48 |
| CHEMBL364782 | — | — | 1 | 6.21 |
| CHEMBL360424 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426062 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL361035 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL366304 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL187113 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL186558 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL364782 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL360424 | — | Ki | = | 1200.0 | nM | 5.92 |