Assay Detail
Binding
CHEMBL877472
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Inhibition of cyclin-dependent kinase 1 activity
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.25 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365411 | — | — | 1 | 5.43 |
| CHEMBL364161 | — | — | 1 | 5.28 |
| CHEMBL191160 | — | — | 1 | 5.27 |
| CHEMBL189998 | — | — | 1 | 5.25 |
| CHEMBL187684 | — | — | 1 | 5.00 |
| CHEMBL188502 | — | — | 1 | - |
| CHEMBL372657 | — | — | 1 | - |
| CHEMBL371169 | — | — | 1 | - |
| CHEMBL177688 | — | — | 1 | - |
| CHEMBL190473 | — | — | 1 | - |
| CHEMBL190371 | — | — | 1 | - |
| CHEMBL361898 | — | — | 1 | - |
| CHEMBL188901 | — | — | 1 | - |
| CHEMBL188904 | — | — | 1 | - |
| CHEMBL189125 | — | — | 1 | - |
| CHEMBL191251 | — | — | 1 | - |
| CHEMBL186412 | — | — | 1 | - |
| CHEMBL188387 | — | — | 1 | - |
| CHEMBL191107 | — | — | 1 | - |
| CHEMBL189226 | — | — | 1 | - |
| CHEMBL188284 | — | — | 1 | - |
| CHEMBL187407 | — | — | 1 | - |
| CHEMBL264769 | — | — | 1 | - |
| CHEMBL363764 | — | — | 1 | - |
| CHEMBL190960 | — | — | 1 | - |
| CHEMBL370951 | — | — | 1 | - |
| CHEMBL190984 | — | — | 1 | - |
| CHEMBL364000 | — | — | 1 | - |
| CHEMBL188386 | — | — | 1 | - |
| CHEMBL188903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365411 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL364161 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL191160 | — | IC50 | = | 5385.0 | nM | 5.27 |
| CHEMBL189998 | — | IC50 | = | 5615.0 | nM | 5.25 |
| CHEMBL187684 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL190371 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL364052 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL361898 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188901 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188904 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL189125 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL191251 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL186412 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL372657 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL189825 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL360401 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL187571 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL365631 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL189947 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL189017 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188536 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL187407 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188903 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188386 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL364000 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL190984 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL370951 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL190960 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL363764 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL264769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL190473 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188284 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL189226 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL191107 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188387 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188502 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL371169 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL177688 | — | IC50 | > | 10000.0 | nM | - |