Assay Detail
Functional
CHEMBL877707
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Concentration of compound required to induce 50 % of the maximum stimulation of alkaline phosphatase activity in Ishikawa cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ishikawa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic acid: a non-steroidal estrogen with functional selectivity for bone over uterus in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.12 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 11.00 |
| CHEMBL41069 | — | — | 1 | 8.64 |
| CHEMBL38797 | — | — | 1 | 8.34 |
| CHEMBL39416 | — | — | 1 | 8.16 |
| CHEMBL36679 | — | — | 1 | 8.07 |
| CHEMBL39227 | — | — | 1 | 7.96 |
| CHEMBL288049 | — | — | 1 | 7.92 |
| CHEMBL289612 | — | — | 1 | 7.77 |
| CHEMBL38776 | — | — | 1 | 7.75 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 7.48 |
| CHEMBL33899 | — | — | 1 | 7.24 |
| CHEMBL36550 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL41069 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL38797 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL39416 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL36679 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL39227 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL288049 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL289612 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL38776 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL83 | TAMOXIFEN | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL33899 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL36550 | — | EC50 | = | 70.0 | nM | 7.16 |