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Compound Detail

CHEMBL36550

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CC/C(=C(\c1ccccc1)c1ccc(/C=C/C(=O)N(C2CCCCC2)C2CCCCC2)cc1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL36550
Phase Preclinical
Structure Type MOL
InChI Key OUTLZIVALFMPOK-RGGNXYEOSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

517.8
MW (Da)
9.56
ALogP
1
HBA
0
HBD
20.3
PSA (Ų)
0.22
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C37H43NO
MW 517.76
Aromatic Rings 3
Heavy Atoms 39
NP-Likeness -0.22

Activity Summary

EC50 1 meas. best 7.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Ishikawa
CHEMBL614649
EC50 7.16 7.16 70.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Ishikawa EC50 = 70.0 nM 7.16 Concentration of compound required to induce 50 % of the maximum stimulation of ... 8201587

Literature References

PubMed DOI Target Context # Activities
8201587 10.1021/jm00037a002 Ishikawa 2

Data from ChEMBL 36 via Core Engine