Assay Detail
Functional
CHEMBL877712
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Inhibition of LPS-induced TNF-alpha secretion from purified human peripheral blood monocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.26 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144649 | — | — | 1 | 6.54 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.50 |
| CHEMBL18701 | RO-201724 | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144649 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL18701 | RO-201724 | IC50 | = | 1800.0 | nM | 5.75 |